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A Brief Story of My Life

  A Brief Story of My Life My childhood unfolded in the town of Võru. Languages were not my strong suit. Russian, Estonian, and English all felt less like tools of communication and more like obstacles to understanding the world. Chemistry and physics, on the other hand, made much more sense. From an early age, I dreamed of leaving the USSR. And to leave — you had to study. So I ended up at Leningrad University. There, chemistry quietly led me to biology, and biology — to DNA. Working with molecules promised, if not freedom, then at least trips abroad. Toward the end of the last millennium, PCR arrived on the scene. This technology amplified not only DNA molecules, but also my departure from the Soviet Union. For ten years straight, I ran a dozen PCR reactions a day — reliably, without holidays. Then came computers and the internet. The next 25 years I spent studying PCR products digitally. At some point, as the saying goes, I had enough of it. I retired. The mission was accomplish...

Wooden Wisdom: How Pinocchio Crashed the Global Economy (And Why It Was Totally Worth It)

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By: Your Friendly Economic Doomsayer WASHINGTON, D.C. — In what economists are now calling “The Great Splintering,” the global financial system finally keeled over last Thursday, coughing up the last breath of fiat currency and coherent trade policy. The collapse was triggered by a genius-level economic strategy cooked up in the dark walnut-paneled walls of the Oval Office by none other than billionaire-turned-presidential advisor, Pinocchio. Yes, Pinocchio — formerly a wooden boy with a lying problem, now a highly lacquered venture capitalist with a thriving TikTok presence and a suspiciously successful hedge fund named “Truth Capital.” The Masterstroke of Madness The crisis began innocently enough: in a televised address dripping with patriotic music and PowerPoint animations, the President (who, for legal reasons, we’ll refer to as “Mango Mussolini”) announced a Global Freedom Tariff — a 700% levy on all imported goods not made in the continental U.S. by bald eagles or certi...

The PowerPoint Singularity

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The PowerPoint Singularity: How Society Collapsed Under the Weight of Slides In the brave new world of modern science, data no longer reigns supreme. The microscope has been replaced by the slide deck, the Petri dish by the bullet point. This is a society where the flickering glow of PowerPoint presentations is all it takes to proclaim groundbreaking discoveries. Gone are the tedious experiments, the soul-crushing peer reviews, and the dreary trudge through statistical significance. Instead, a well-timed fade transition or an elegantly crafted pie chart is all that is needed to rewrite the laws of the universe. The Rise of the PowerPoint Paradigm The pivot to PowerPoint began innocuously enough. Researchers, exhausted from the grind of grant applications and inconclusive results, realized that nobody read their papers anyway. What really mattered was the  presentation . Could you captivate your audience with slick visuals, a catchy title, and a colorful metaphor that compared mitoc...

Highthroughput Genomics Express From Hell

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Molecular Biology Lab recruiting poster

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Grand Replication Hypothesis

Prompt: Each living cell goes through life cycles: birth - action - death. Death is not terminal since genetic information is transmitted into progeny cells. This is how life forms evolve and became at some point immortal. Though the biological life forms are encapsulated within the Universe. Universe itself goes through life cycles from birth to death. At some stages of evolution biological forms gain intelligence (humans for example) which may affect the path of further development of the Universe. Could you imagine possible scenario how human intelligence can affect evolution of the Universe and prevent it from terminal collapse in such way that all information in decaying universe is passed to the new one. I call it grand replication hypothesis.  ChatGPT: The Grand Replication Hypothesis envisions a future where human intelligence plays a role in the life cycle of the Universe itself, ensuring continuity by transferring information from a decaying Universe to a new one. This c...

Announcement of new genome sequencing project

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Data recovery from crashed file server

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Finding the right sample

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High throughput express

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Data hoarding

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Low input, high throughput, no output biology

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 Working on Generating Supporting Data for a Favored Scientific Model  ---==+++==--- Collapse of the Main Hypothesis  ---==+++==--- Execution of a Lab Member for Generating Data That Does Not Support the Main Hypothesis  ---==+++==--- Genome Assembly Finalization Prior Submission to the NCBI GenBank ---==+++==--- Visualization of Protein Interaction Networks  ---==+++==--- Low input, high throughput, no output biology 

The Reversal (backward metamorphosis)

  In the depths of a bustling molecular biology lab, nestled among the gleaming machines and petri dishes, was the newest member of the research team, Gregory. Unlike his colleagues, Gregory had only recently become a human; up until last week, he had been a cockroach, scuttling about in the dark recesses of the lab's basement. Fate, with a twisted sense of humor, had decided it was his turn to stand upright and carry a pipette. Gregory’s transition from cockroach to human was nothing short of miraculous, courtesy of a bizarre genetic splicer mishap. Now, instead of scrounging for crumbs, he had to analyze DNA sequences and contribute to the groundbreaking research on genome editing. The irony was not lost on him: once considered a pest, he was now researching pest-resistant crops. The lab was a labyrinth of equipment he couldn’t begin to comprehend. His new colleagues, unaware of his entomological origins, praised the fresh perspective he brought to the team. "Gregory, your a...

ChatGPT’s vision of the scientists in Hell inspired by Hieronymus Bosch artwork

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GPT-4 DALL·E 3 ART

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  Oil painting of a DNA double helix structure, inspired by Kandinsky's style. The painting should reflect abstract shapes, vibrant colors, and a sense of rhythm and movement. The DNA strands should twist and turn, intertwined with colorful abstract shapes and patterns that evoke a sense of musicality. Oil painting of a DNA double helix structure, inspired by Malevich's Suprematist style. The background should be minimalist, with the DNA strands rendered as geometric shapes, especially squares and rectangles. Stark contrasts in color should be used, with the DNA structure standing out prominently against the background.  Oil painting of a DNA double helix structure, inspired by Salvador Dali's surrealistic style. The DNA strands should melt and twist in a dreamlike manner, set against a fantastical landscape. Detailed representations of other elements, such as clocks or animals, can be incorporated, making the scene appear as if from a dream or alternate reality.   Oil pa...